Immune responses to recombinant Brugia malayi pepsin inhibitor homolog (Bm-33) in patients with human lymphatic filariaisis
Identifieur interne : 005850 ( Main/Exploration ); précédent : 005849; suivant : 005851Immune responses to recombinant Brugia malayi pepsin inhibitor homolog (Bm-33) in patients with human lymphatic filariaisis
Auteurs : N. S. A. Krushna ; C. Shiny ; G. Manokaran ; S. Elango ; S. Babu ; R. B. NarayananSource :
- Parasitology research [ 0932-0113 ] ; 2010.
Descripteurs français
- KwdFr :
- ADN complémentaire (biosynthèse), ADN complémentaire (génétique), ADN complémentaire (métabolisme), Activation des lymphocytes (), Activation des lymphocytes (immunologie), Agranulocytes (), Agranulocytes (immunologie), Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (immunologie), Antigènes d'helminthe (usage thérapeutique), Brugia malayi (immunologie), Cellules cultivées, Cytokines (génétique), Cytokines (métabolisme), Facteurs immunologiques (immunologie), Facteurs immunologiques (usage thérapeutique), Filariose lymphatique (immunologie), Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Humains, Immunité cellulaire (), Immunité cellulaire (immunologie), Lymphocytes T (), Lymphocytes T (immunologie), Prolifération cellulaire (), Protéines d'helminthes (immunologie), Protéines d'helminthes (usage thérapeutique), Protéines recombinantes (immunologie), RT-PCR, Régulation de l'expression des gènes ().
- MESH :
- biosynthèse : ADN complémentaire.
- génétique : ADN complémentaire, Cytokines.
- immunologie : Activation des lymphocytes, Agranulocytes, Antigènes d'helminthe, Brugia malayi, Facteurs immunologiques, Filariose lymphatique, Immunité cellulaire, Lymphocytes T, Protéines d'helminthes, Protéines recombinantes.
- métabolisme : ADN complémentaire, Cytokines.
- sang : Anticorps antihelminthe, Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Antigènes d'helminthe, Facteurs immunologiques, Protéines d'helminthes.
- Activation des lymphocytes, Agranulocytes, Animaux, Cellules cultivées, Humains, Immunité cellulaire, Lymphocytes T, Prolifération cellulaire, RT-PCR, Régulation de l'expression des gènes.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (blood), Antigens, Helminth (immunology), Antigens, Helminth (therapeutic use), Brugia malayi (immunology), Cell Proliferation (drug effects), Cells, Cultured, Cytokines (genetics), Cytokines (metabolism), DNA, Complementary (biosynthesis), DNA, Complementary (genetics), DNA, Complementary (metabolism), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Gene Expression Regulation (drug effects), Helminth Proteins (immunology), Helminth Proteins (therapeutic use), Humans, Immunity, Cellular (drug effects), Immunity, Cellular (immunology), Immunologic Factors (immunology), Immunologic Factors (therapeutic use), Leukocytes, Mononuclear (drug effects), Leukocytes, Mononuclear (immunology), Lymphocyte Activation (drug effects), Lymphocyte Activation (immunology), Recombinant Proteins (immunology), Reverse Transcriptase Polymerase Chain Reaction, T-Lymphocytes (drug effects), T-Lymphocytes (immunology).
- MESH :
- chemical , biosynthesis : DNA, Complementary.
- chemical , blood : Antibodies, Helminth.
- chemical , genetics : Cytokines, DNA, Complementary.
- chemical , immunology : Antigens, Helminth, Helminth Proteins, Immunologic Factors, Recombinant Proteins.
- chemical , metabolism : Cytokines, DNA, Complementary.
- chemical , therapeutic use : Antigens, Helminth, Helminth Proteins, Immunologic Factors.
- blood : Elephantiasis, Filarial.
- drug effects : Cell Proliferation, Gene Expression Regulation, Immunity, Cellular, Leukocytes, Mononuclear, Lymphocyte Activation, T-Lymphocytes.
- drug therapy : Elephantiasis, Filarial.
- immunology : Brugia malayi, Elephantiasis, Filarial, Immunity, Cellular, Leukocytes, Mononuclear, Lymphocyte Activation, T-Lymphocytes.
- Animals, Cells, Cultured, Humans, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Immune responses to recombinant
Url:
DOI: 10.1007/s00436-010-2081-x
PubMed: 20927633
PubMed Central: 3515686
Affiliations:
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Le document en format XML
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pepsin inhibitor homolog (Bm-33) in patients with human lymphatic filariaisis</title>
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pepsin inhibitor homolog (Bm-33) in patients with human lymphatic filariaisis</title>
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<series><title level="j">Parasitology research</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Helminth (blood)</term>
<term>Antigens, Helminth (immunology)</term>
<term>Antigens, Helminth (therapeutic use)</term>
<term>Brugia malayi (immunology)</term>
<term>Cell Proliferation (drug effects)</term>
<term>Cells, Cultured</term>
<term>Cytokines (genetics)</term>
<term>Cytokines (metabolism)</term>
<term>DNA, Complementary (biosynthesis)</term>
<term>DNA, Complementary (genetics)</term>
<term>DNA, Complementary (metabolism)</term>
<term>Elephantiasis, Filarial (blood)</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Helminth Proteins (immunology)</term>
<term>Helminth Proteins (therapeutic use)</term>
<term>Humans</term>
<term>Immunity, Cellular (drug effects)</term>
<term>Immunity, Cellular (immunology)</term>
<term>Immunologic Factors (immunology)</term>
<term>Immunologic Factors (therapeutic use)</term>
<term>Leukocytes, Mononuclear (drug effects)</term>
<term>Leukocytes, Mononuclear (immunology)</term>
<term>Lymphocyte Activation (drug effects)</term>
<term>Lymphocyte Activation (immunology)</term>
<term>Recombinant Proteins (immunology)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>T-Lymphocytes (drug effects)</term>
<term>T-Lymphocytes (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN complémentaire (biosynthèse)</term>
<term>ADN complémentaire (génétique)</term>
<term>ADN complémentaire (métabolisme)</term>
<term>Activation des lymphocytes ()</term>
<term>Activation des lymphocytes (immunologie)</term>
<term>Agranulocytes ()</term>
<term>Agranulocytes (immunologie)</term>
<term>Animaux</term>
<term>Anticorps antihelminthe (sang)</term>
<term>Antigènes d'helminthe (immunologie)</term>
<term>Antigènes d'helminthe (usage thérapeutique)</term>
<term>Brugia malayi (immunologie)</term>
<term>Cellules cultivées</term>
<term>Cytokines (génétique)</term>
<term>Cytokines (métabolisme)</term>
<term>Facteurs immunologiques (immunologie)</term>
<term>Facteurs immunologiques (usage thérapeutique)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filariose lymphatique (sang)</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
<term>Humains</term>
<term>Immunité cellulaire ()</term>
<term>Immunité cellulaire (immunologie)</term>
<term>Lymphocytes T ()</term>
<term>Lymphocytes T (immunologie)</term>
<term>Prolifération cellulaire ()</term>
<term>Protéines d'helminthes (immunologie)</term>
<term>Protéines d'helminthes (usage thérapeutique)</term>
<term>Protéines recombinantes (immunologie)</term>
<term>RT-PCR</term>
<term>Régulation de l'expression des gènes ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>DNA, Complementary</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytokines</term>
<term>DNA, Complementary</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term>
<term>Helminth Proteins</term>
<term>Immunologic Factors</term>
<term>Recombinant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
<term>DNA, Complementary</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antigens, Helminth</term>
<term>Helminth Proteins</term>
<term>Immunologic Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>ADN complémentaire</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term>
<term>Gene Expression Regulation</term>
<term>Immunity, Cellular</term>
<term>Leukocytes, Mononuclear</term>
<term>Lymphocyte Activation</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN complémentaire</term>
<term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Agranulocytes</term>
<term>Antigènes d'helminthe</term>
<term>Brugia malayi</term>
<term>Facteurs immunologiques</term>
<term>Filariose lymphatique</term>
<term>Immunité cellulaire</term>
<term>Lymphocytes T</term>
<term>Protéines d'helminthes</term>
<term>Protéines recombinantes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term>
<term>Elephantiasis, Filarial</term>
<term>Immunity, Cellular</term>
<term>Leukocytes, Mononuclear</term>
<term>Lymphocyte Activation</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ADN complémentaire</term>
<term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term>
<term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antigènes d'helminthe</term>
<term>Facteurs immunologiques</term>
<term>Protéines d'helminthes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Agranulocytes</term>
<term>Animaux</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Immunité cellulaire</term>
<term>Lymphocytes T</term>
<term>Prolifération cellulaire</term>
<term>RT-PCR</term>
<term>Régulation de l'expression des gènes</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Immune responses to recombinant <italic>Brugia malayi</italic>
pepsin inhibitor homolog (rBm-33) were investigated in patients with human lymphatic filariasis (microfilaremics (MF) and chronic pathology (CP)) along with endemic normals (EN). Flow cytometric analysis (24 h) revealed CD4<sup>+</sup>
T cell activation in patients (MF and CP) compared to normals (EN), with increased expression of CD69 and diminished levels of CD62L and CD127. This was associated with an elevated expression of CD154 but not CD28 and CTLA4 in CP patients. However, Bm-33-induced cytokine expression profile (IL-1β, IL-12, IL-8, IFN-γ, IL-10 and TGF-β) did not exhibit any significant difference between normals and patients at the same time point. Although CD4<sup>+</sup>
T cell activation was observed initially in filarial patients (24 h), lymphoproliferation studies (96 h) suggested diminished proliferation compared to normals, indicating functional inactivation in the former upon prolonged antigen exposure. This indicates that rBm-33 induces an early T cell activation in MF and CP patients followed by a decreased lymphoproliferation that might contribute to immune suppression in these individuals.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Babu, S" sort="Babu, S" uniqKey="Babu S" first="S." last="Babu">S. Babu</name>
<name sortKey="Elango, S" sort="Elango, S" uniqKey="Elango S" first="S." last="Elango">S. Elango</name>
<name sortKey="Krushna, N S A" sort="Krushna, N S A" uniqKey="Krushna N" first="N. S. A." last="Krushna">N. S. A. Krushna</name>
<name sortKey="Manokaran, G" sort="Manokaran, G" uniqKey="Manokaran G" first="G." last="Manokaran">G. Manokaran</name>
<name sortKey="Narayanan, R B" sort="Narayanan, R B" uniqKey="Narayanan R" first="R. B." last="Narayanan">R. B. Narayanan</name>
<name sortKey="Shiny, C" sort="Shiny, C" uniqKey="Shiny C" first="C." last="Shiny">C. Shiny</name>
</noCountry>
</tree>
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</record>
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